Thursday, 24 November 2016

Pneumonia Vaccine to be introduced under Universal Immunization Programme in 2017


Pneumonia and diarrhoea are major reasons for death in the post-neonatal period. In 2015, India recorded an under-five death rate of around 48 deaths for each 1,000 live births. It is serious situation as around 1.26 million children aged below five years die in the country every year.

In a recent report released by International Vaccine Access Centre (IVAC) and Johns Hopkins Bloomberg School of Public Health, the top five countries with highest burden of child pneumonia & diarrhoea cases globally are India, Nigeria, Pakistan, Democratic Republic of Congo and Angola. The report also stated that 15 years after pneumococcal conjugate vaccines’ (PCV) first introduction globally in 2000, five of the highest pneumonia burden countries (India, Indonesia, Chad, China and Somalia) are still not using the vaccine in their routine immunisation programs.

Post the report launch, Ministry of Health and Family Welfare(MoHFW) announced that the pneumococcal conjugate vaccines(PCV) that combats pneumonia, will be rolled out as part of the Universal Immunisation Programme in a phased manner in the states of Himachal Pradesh, Uttar Pradesh, Bihar, Madhya Pradesh and Rajasthan. The introduction of the vaccine will start in 2017.

"Adding this life-saving vaccine such as PCV and Rotavirus to our immunization program will not only improve the health of our children but will also reduce hospitalisation and other conditions associated with diarrhoea and pneumonia such as malnutrition, delayed physical and mental development among children," said Union Health Minister Shri J P Nadda. 

There are still many conversations with the cost issues related to the newly introduced vaccine. In private sector, three doses of PCV will cost around Rs 15,000. Dr Pradeep Haldar, Deputy Commissioner (Immunization), Union Health Ministry has stated that the vaccine will be supported by Global Alliance for Vaccines and Immunization(GAVI) initially and later Ministry of Health will acquire vaccines under Government of India’s programme at subsidized costs.

The introduction of the PCV vaccine is a commendable move by the Ministry and would help in saving a lot of lives. The recently introduced PCV and Rotavirus vaccine will help in reducing hospitalisation rates in children prone to Pneumonia and Diahhroea, which will hence reduce the economic burden on the family and the health cost burden on the country.
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Monday, 31 October 2016

Cholera Vaccines: Need of the Hour in Haiti


Haiti, the Caribbean nation has been frequently hit by natural disasters like hurricanes, floods and has also been struck by powerful earthquakes. In 1963, Hurricane Flora killed 6,000 people in Haiti and Cuba. During the hurricane season eight years ago, Haiti was hit by four storms- Fay, Gustav, Hannah and Ike, which killed more than 800 people and devastated nearly three fourth of its agricultural land. The country has also suffered dire flooding in 2002, 2003, 2006 and 2007. Devastating earthquake flattened parts of the capital, Port-au-Prince in 2010. It killed at least 90,000 people and displaced more than 1.5 million.

With so many natural calamities, Haiti had witnessed many Cholera outbreaks in the recent past. Cholera which causes severe diarrhea, is spread through contaminated water and has a short incubation period, which leads to rapid outbreaks. The major earthquake in 2010 claimed about 10,000 lives due to Cholera. 771 Cholera cases have been reported every week in 2016, with 28,559 cases in the last ten months.

Hurricane Matthew which hit the country on 4th October has hit the country hard. More than 200,000 homes have been severely damaged and 175,000 people are still living in temporary shelters across the country. Since the storm, health workers have diagnosed more than 200 people with cholera, and 13 have died. As per WHO figures, 35 of 197 health facilities in Haiti, including hospitals, clinics and treatment centres have been affected by the floods and heavy winds following the hurricane.

International organizations like Gavi and WHO have announced that they will be sending doses of Cholera Vaccine in order to protect Haitians against the growing threat of cholera outbreak. According to Dominique Legros, cholera expert at the WHO, since Hurricane Matthew hit the island there has been a sharp increase in cholera cases, with more than 200 suspected cases reported since the storm hit. Public health officials have already indicated that there is a high risk of cholera transmission in the worst hit areas and the assessment will help in drawing an effective roadmap for the emergency vaccination programme in the country.

“Gavi will continue to work closely with the Government of Haiti and with our global health colleagues to stave off the potential threat of cholera outbreaks and enable the Haitian people to stay healthy and focused on repairing the damage caused by Hurricane Matthew.” said Dr. Seth Berkley, CEO of Gavi.

Though International organizations are working towards stopping another Cholera outbreak through vaccines, supplies are still low to reach the high number of people at risk. According to Justin Lessler, an associate professor of epidemiology at Johns Hopkins Bloomberg School of Public Health "the people who need cholera vaccine are generally the poorest people. People with money generally have the ability to get clean water, stay away from cholera"

Cholera is endemic in over 50 countries with estimated mortality of 100,000-120,000 deaths and a morbidity of 3.8-4.4 million annual cases attributed to this disease. There is an urgent need of highly effective and affordable Cholera vaccines both for outbreaks as well as mass vaccination campaigns.
The huge Cholera burden has led to a demand for an effective, low-cost Cholera vaccine for use in epidemic outbreaks as well as for mass vaccinations in endemic settings. A market also exists for travellers to endemic regions. Demand estimates for Cholera vaccines vary significantly across scenarios with an expected 30 million doses needed by 2016 rising to expected 200 million doses by 2025, assuming vaccination of all 1-14 year old patients in high risk populations. Global public health community has also expressed concern that current Cholera vaccine manufacturers may not be able to meet the projected increase in demand further strengthening the requirement for alternate, low-cost vaccine supply.

Hilleman Laboratories in collaboration with Gotovax AB (a University of Gothenburg spin-off biopharmaceutical company) aims to deliver a high impact Oral Cholera vaccine at a significantly more affordable price than the ones currently available in the market. Easy to administer, with cross protection against ETEC diarrhea and enhanced with a longer shelf life, this vaccine candidate will be most suited for geographies with the highest cholera burden like Africa and South Asia.

Hilleman Laboratories has also recently announced the signing of an MoU with ICDDR,B and Incepta Vaccine Ltd, both based in Bangladesh for further development and manufacturing of our vaccine.
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Tuesday, 25 October 2016

Securing Our Children’s Future



"Early childhood development will not only benefit the children of today, but will have a direct impact on the stability and prosperity of nations in the future".
-Dr. Margaret Chan, Director-General, WHO

Malnutrition and infection account for a large proportion of the mortality and morbidity that prevails in developing countries, especially among vulnerable groups of infants and young children. Millions of lives are being lost every year from disease for which there are vaccines. Hence, meeting the basic needs of nutritional wellbeing and addressing malnutrition in its various forms among children is therefore an urgent global priority.

Hilleman Laboratories also understands and recognizes the importance of interplaying role of nutrition and immunity, along with vaccination in reducing childhood mortality and improving child health and development. With an objective of ‘Improving Infant and Child Health’, Hilleman Laboratories recently organized ‘Securing Our Children’s Future’ a workshop on nutrition and immunity for infant and child health. The workshop brought together research scientists, academicians, nutritionists, medical community and policy makers and provided a platform to discuss the latest development, practices and challenges in the field of nutrition and immunity.

The workshop took place in New Delhi, on the 21st and 22nd of September, 2016. With speakers and participants from diverse backgrounds, the workshop started with opening remarks by Dr. Davinder Gill, Chief Executive Officer (CEO), Hilleman Laboratories. The first speaker of the workshop was Professor Gagandeep Kang, Christian Medical College (Vellore), who was able to set in the context with her keynote presentation on ‘Malnutrition and Vaccine Response’. She explained how malnutrition is the most common immunodeficiency globally through case studies and statistics. Professor Kang shared insights and cases on three key areas-1) Immunology of malnutrition 2) Vaccination in the context of malnutrition and 3) Malnutrition in the context of vaccination.

Followed by the insightful keynote presentation, Dr. Prema Ramachandran, Director, Nutrition Foundation of India (New Delhi) began Session 1 on ‘Nutritional Epidemiology for Infant and Child health by giving an overview of health and nutritional status of Indian children. She spoke about the challenges, interventions and achievements in the area of infant and child nutrition. Dr. Ramachandran also discussed the current status of World Health Assembly targets on low birth weight rates, breast feeding rates, and also stunting and wasting rates. Dr. Shweta Khandelwal from Public Health Foundation of India (New Delhi) continued the session and spoke on ‘Importance of nutrition in chronic diseases’. She threw light on the impact of changing diet patterns, nutrients and food items on chronic diseases. The session was wrapped up by Dr. Uma Chandra Mouli Natchu from Translational Health Science and Technology Institute (Faridabad) who spoke on ‘Early life nutritional influences on immunity’. Dr. Natchu shared some interesting facts on how Vitamin D deficiency leads to higher risk of respiratory syncytial virus (RSV) infections, ultimately leading to Asthma. He also revealed how daily zinc supplementation in childhood reduces incidence of pneumonia & all-cause mortality.

Second session on ‘Nutrition for Children’ was initiated by Dr. Sumathi Swaminathan from St. John’s National Academy of Health Sciences (Bengaluru). Dr. Swaminathan spoke about ‘Nutritional requirements in infants & children’. She talked about changes in nutrition requirements during infancy and young childhood and also covered key aspects of feeding. She also highlighted that how the existence of breast milk banks is fruitful and how they have been successful in many parts of the country. Dr. Swaroop Kumar Sahu from Jawaharlal Institute of Postgraduate Medical Education and Research (Puducherry) proceeded further with the session with the discussion on the topic ‘Effects of malnutrition in children’ which highlighted on the spectrum of malnutrition and the growth charts to monitor the malnutrition. Furthermore, both the direct and indirect effects of malnutrition on children were discussed along with the interventions to address the problem of malnutrition among children. Dr. Nisha Wadhwani continued the session and spoke on behalf of Dr. Sadhana Joshi from Bharati Vidyapeeth University (Pune) on the topic of ‘Prenatal maternal Nutrition’ which focussed on the direct effect of maternal nutrition on fetal programming and also threw light on the role of the epigenetic modification in altering placental function and fetal development. The last presentation of the second session was made by Dr. Anju Pradhan Sinha from Indian Council of Medical Research (New Delhi) on the ‘Intestinal Microbiota and the role of probiotics in child health’ and it gave a glimpse on the importance of the gut flora and its role in human immune functions and showcased case studies of using different probiotics for prevention of neonatal infection.

Day 1 of the workshop ended with Dr. Anjali Ahuja from Nestle Nutrition (Gurgaon) speaking about ‘Complementary Feeding - Role of Critical micronutrients in Paediatric nutrition’. Dr. Ahuja showcased how micronutrient deficiencies are linked to poor growth, intellectual impairment & increased risk of morbidity & mortality. She spoke about fortified complementary feed and its impact on infant and child health. Dr. Ahuja also covered key initiatives by Nestle Nutrition and how the organization is committed to the well-being and overall health of children.

The second day of the workshop started with Ms. Ruchika Chugh Sachdeva from PATH speaking on Role of nutrition in prevention of disease’. She started the fourth session by drawing audience attention to the relationship of nutrition with health and disease. She focused on the link between nutrition and immunity with respect to macronutrient & micronutrient deficiency, and over-nutrition. Ms. Sachdeva also spoke about food fortification and stated various facts related to the same. She ended her presentation with interesting quote by Thomas Edison-

“The doctor of the future will no longer treat the human frame with drugs, but rather will cure and prevent disease with nutrition”

The session proceeded with Dr. B S Ramakrishna from SRM Institute of Medical Science (Chennai), who spoke on ‘Environmental Enteropathy’. The key areas covered in his presentation were tropical enteropathy, and consequences of enteropathy and how it is measured. Dr. Ramakrishna also gave examples of cases highlighting relationship of stunting with diarrhoea. The fourth session was concluded by Dr. Ira Praharaj from Christian Medical College (Vellore) who addressed the audience on ‘Probiotics and the response to vaccines’ highlighting the immunomodulation by the gut microbiota and probiotics. Through her talk she emphasized on one of the key questions on the role of probiotics to improve/affect immune responses to vaccines by discussing various case studies.

Dr. Francis Odhiambo from UNICEF India (New Delhi) took the last session of the workshop, and delivered a presentation on the pertinent topic of ‘Integrated approaches to address underlying risks’. He spoke on Water, Sanitation and Hygiene Programme (WASH) and various interventions executed by UNICEF, related to water quality, sanitation, safe handling and storage, hand washing with soap. The final presentation was given by Dr. Vanisha S Nambiar from Maharaja Sayajirao University of Baroda (Vadodara). Dr. Nambiar spoke on Nutritional programming (nutritional education and counselling programs). She took the audience through the various stages of change, in case of nutritional programming. She explained how nutrition education as well as counselling has a high potential in bringing about a behavioural change.

Dr. Davinder Gill concluded the workshop by calling it “A truly successful endeavour, which saw participation from cross disciplinary set of speakers, attendees, stakeholders and other members of the community who came together and shared insightful details on key topics like advocacy, clinical trials and some recent scientific innovations that are happening around the country, which in totality is helping to build a strong case for the interplaying role of nutrition and immunity as the key factors along with vaccination in reducing childhood mortality and improving child health and development”. He also underlined the significance of such workshops in building new friendships and collaborations.


Through this workshop, Hilleman Laboratories was successfully able to provide a platform for meaningful discussions which could help resolve gaps related to public health issues on infant and child health and at the same time provided a great opportunity for the nutrition focal managers to be oriented on key technical updates on child nutrition and immunity. 
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Friday, 30 September 2016

Improving Efficiency of Vaccination Systems through Intelligent Vaccine Management


The Ministry of Health and Family Welfare has been working towards reducing morbidity and mortality from vaccine-preventable diseases through its Universal Immunization Programme (UIP). The ministry has introduced numerous initiatives to improve the vaccine coverage in the country but there are still critical gaps in the vaccine logistics management system in the country with issues related to inadequate and poor infrastructure, weak monitoring and management information system, vaccine management and issues related to technical capacities of staff.

Districts around the country have been facing challenges related to vaccine coverage because of frequent equipment breakdowns, overstocking and stock-outs, inadequate monitoring and supervision, high rates of breakdown of equipment, overstocking and stock-outs, inadequate monitoring and supervision, and poor management. To overcome these challenges the Ministry of Health and Family Welfare (MoHFW) in partnership with United Nations Development Programme (UNDP) and GAVI are rolling out Electronic Vaccine Intelligence Network (eVIN) across 12 states in India.

eVIN helps in addressing three critical questions in vaccines logistics management - where vaccines are; whether they are in adequate quantities; and whether they are stored at recommended temperatures?

The eVin system uses a three prompt approach of people, processes and product. The Electronic Vaccine Intelligence Network (eVIN) is a technology system that digitizes vaccine stocks through a smartphone application. The technology uses mobile and web based dashboards to track locations, temperatures and stock levels of vaccines, making sure that the supply is safe and reliable. The system helps in providing real time data that can be viewed on a web and application-based dashboard by programme managers across districts, states and national levels. All the data is uploaded on a cloud based server by trained professionals through a smartphone application.

“Seeing health workers being able to show on their smartphones, real time data and having temperature monitoring that can be monitored externally is a really powerful thing” said Dr Seth Berkley, CEO of GAVI, the Vaccine Alliance.

With the eVIN system recently being rolled out in districts of Assam, Rajasthan, Bihar, Chhattisgarh, Gujarat, Himachal Pradesh, Jharkhand, Manipur, Nagaland and Odisha; policymakers will be able to make data-informed decisions in planning for vaccine distribution and improving supply chain. As India is the home to the world’s largest birth cohort, planning a healthy future for every child is very essential at all levels.
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Monday, 5 September 2016

Companies Targeting The Poor Yet Retaining Profits


Innovation is a change that unlocks new value.”
-  Jamie Notter

Innovations in today’s time have paved way for the Multi-National Companies to reach out to people, catering to their needs and making their life simple and easy. It is so phenomenal that companies who sell products targeting customers at the poverty line still manage to make profits despite selling the products at very lower cost.

In order to understand the different facets of such companies’ marketing approach,  Amrit Gill a sophomore, majoring in Business & Finance at the University of South Florida completed a project on a very distinctive area of interest- ‘How companies retain profits while selling goods at a cheap price to consumers at the poverty line’. His initial research showed that such companies face difficulties finding customers in the starting, but after changing their business model and tactics they are able to become profitable. Such companies manoeuvre helps develop a case for other companies to analyze the consumer behavior and compeer their business and marketing approach.

1.       Green Light Planet- Sun King

The product originated in Orissa, is made by two Indian and one American college student in order to improve agricultural productivity, but the villagers later utilised it as a source of electricity. It’s estimated that around two billion population of the world lives in darkness and this product comes as a life-saver by illuminating their lives with bright light. The product is an alternative to the pollution causing kerosene lamps and also reduces the risk of catching fire. The company has sold around 3,000,000 lamps with 6,000 active sellers across India, Kenya and Uganda. The product will be able to add up to 30,000 sellers.

Nearly 20% of the Indian population do not have access to electricity and dwells heavily on kerosene lamps. Kerosene is one of the sources for global warming and also responsible for lung cancer, strokes and other respiratory diseases. With the Green Light Planet’s product Sun King coming into picture will help in reducing such issues. The development of this product took approximately 3 years. The initial investors in this product were from ZS Associates.

 The marketing strategy of Green Light Product was different. They tried to convince important people in the villages such as teachers, police and other officials to gain their trust, as the villagers had a bad experience with the Chinese products of such kind breaking down at a very early level of usage.

After their products were successful among few people, they encouraged their customers to spread its importance by Word of Mouth. In order to gain more trust they partnered with an NGO who helped them in adding more customers to their bucket.

In the near future the company plans to expand with adding more products such as cooking stoves and water filtration systems, once they are able to reach the saturation levels. The company’s projecting a 5-7 year sustainability programme, then depending upon their market they will expand on the product range.

2.       Mpedigree

An organization started by Bright Simmons, an entrepreneur who wanted to terminate counterfeit drug production in Ghana. The company produces labels in order to regulate the sales of counterfeit products. Mpedigree initially worked with pharmaceutical companies, but has now expanded to electrical products, clothing, cosmetics and seeds used in agriculture.

For developing the product, Simmons hired engineers to develop software that creates unique 12 digit codes, which is printed on a label in China costing $0.09 per unit. The software was used to store the codes in a database, in- case when a customer texted the code they were able to receive instant counterfeit verification. It came as valuable tool for manufacturers as they were able to get notifications if the code had been used more than once.

Pharmaceutical companies, venture capitalists, and regulators for future investments/partnerships did not take Mpedigree seriously, because it was a small nonprofit organization and charities were not much successful in Ghana. In 2009 Simmons transformed his organization into a for-profit social enterprise, he made calls until he obtained a meeting with Hewlett Packard to obtain cloud servers for data storage and partnership. HP saw initiative in the rising mobile industry in West Africa and East Asia. In December 2010 HP announced that it would run the data that host Mpedigree’s code, which saved the company 10 million dollars or the infrastructure costs. The pharmaceutical world started taking the company seriously when Nigeria’s food and drug administration endorsed Mpedigree.

Mpedigree is developing a system, in which the customers and the seller can contact each other directly in order to ensure customer satisfaction. They are in the process of presenting the idea to various telecom mobile carriers in India and Nigeria.  The company has expanded to the cosmetic and textile industries and is on the verge of signing 7 new deals, 5 in Ghana and 2 in Nigeria.

What Hilleman Laboratories can do?

Hilleman laboratories can increase the transaction size by using upselling. They can increase the total number products sold to a consumer by selling upgrades or additional accessories. The organization should negotiate long term supply deals in order to buy the products for lower prices and create better terms with the supplier.
The organization can incorporate efficient promotion by effectively using promotion expenses to create as many connections as possible. This will help increase sales volume, which can lead to a larger profit margin.

There is also a need to reduce cost of production which can be done by reducing energy consumption, and taking precautionary steps to prevent accidents. The organization should focus on avoiding overproduction and reducing waste.
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Tuesday, 23 August 2016

Workshop on Nutrition and Immunity for Infant and Child health


MSD-Wellcome Trust Hilleman Laboratories is a first of its kind joint venture between Merck & Co., USA and Wellcome Trust, UK Hilleman Laboratories is dedicated for improvement of child health by developing affordable vaccines for the developing world.

It is well known that appropriate functioning of the human immune system is dependent on nutritional status. There are a lot of insights gathered about interrelationship between nutrition and immunity and its role in reducing childhood morbidity and mortality.
Hilleman Laboratories understands and recognizes this interplaying role of nutrition and immunity in improving child health and its impact on the economic sustainability of our nation. To further our understanding of this key area, Hilleman Laboratories aims to convene a workshop on 21st and 22ndSeptember 2016 in NewDelhi, India. The workshop plans to provide a platform to spur a dialogue between esteemed academicians, researchers, public health experts and policy makers responsible for planning nutrition programs across the country. The workshop will have key-note presentation, theme presentations and discussions.

The workshop scopes to address the two-way association between nutrition with immune parameters in infants and young children. Infancy and early years of a child’s development represents the most nutritionally vulnerable stage of life cycle. Young children pay a lifelong price of undernutrition. Improvement in nutrition status is vital for saving young lives and thereby creating an impact on economic sustainability of a nation. The impact of nutrition is multi-faceted. Nutrition in early years of life is known to make a huge impact on immunity of an individual.

The workshop aims to cover key topics like integrating role of nutrition and immunity and provide insight for the nutrition focal persons/managers on key technical updates on child nutrition and immunity. Some of the key topics to be covered are: Nutrition requirements of children, Nutritional epidemiology for infant and child health,Nutritional deficiency associated Immune disorders in infants and children and Role of nutrition in prevention of disease, environmental eneteropathy, vaccines and nutritional health.

The first segment of this workshop session will throw light on importance of nutrition on immunity in infants and young children. It aims to landscape the trends and determinants in infant and child nutritionacross the country . The second segment aims to appraise and evaluate the nutritional requirements of infants and young children, and consider prenatal nutrition too. The third segment will shed light on ill effects of poor nutrition and its adverse impact on physical and cognitive growth of children.The fourth session will focus on how good nutrition in early years can strengthen immunity or vaccination against a disease can be chosen to prevent disease. It is well known that nutrition status alters response to vaccine and therefore, this session will explore the concept in conjunction with the role of environmental factors for infants and child health. The fifth and final session is planned to focus on the promotion of good health through nutrition and primary prevention of nutrition related illness in infants and young children. Apart from discussions on nutritional education and counseling programs for children, this session is also aimed to address integrated issues such as sanitation and hygiene which could indirectly affect infant and child health.

This workshop thus aims to highlight and resolve the gaps in current scenario while discussing malnutrition, immunity and vaccinesby providing a great opportunity to distinguished professionals to discuss the latest advancement, practices and challenges in the field to achieve the common goal of improving infant and child health. 

To register log on to http://www.hillemanlabs.org/registration.aspx
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Thursday, 11 August 2016

Undernutrition And Diminished Immunity: Breaking The Lethal Cycle


Healthy children are the bedrock of a healthy society. Good nutrition is the core pillar for healthy and productive communities and nations. The benefits of good nutrition are carried across generations, binding and supporting various facets of nation’s development. Hence it is in a nation’s best interest to safeguard its children’s health. As per UNICEF, around 3 million children die due to undernutrition every year. Asia alone is believed to be home to approximately 70% of the world's malnourished children, while India has the highest percentage of undernourished children in the world. Ironically when the economic development of India is growing at nearly 10% annually, the rate of undernourished children remain very high. As per the third National Family Health Survey (NFHS) India, 48% of children under the age of five are stunted due to chronic undernutrition. Undernutrition, often referred to as “hidden hunger”, is a form of malnutrition. It has long been a sore point for India, adversely impacting the overall social and economic development.

Without aggressive efforts, the undernutrition issue in India is escalating with devastating consequences on children’s development-physical growth retardation, increased susceptibility to diseases, hampered cognitive development.

Undernutrition issues among the age of under-five children is an important concern for the health authorities in India. It is acknowledged widely that infections are as much a cause of malnutrition as they are a consequence. Malnourished children have increased risk of mortality from infectious diseases. Investing in elevating maternal and child nutritional status is a long-term investment that will benefit the present generation and their children as well.
The nutrition of mothers and children is closely linked. When malnutrition starts at conception, most of the damage is already done as the child enters the second year of life. The first 1000 days of a child’s life is a critical window and represents the most vulnerable period to the impact of poor nutrition. Deficits during this period can have irreversible consequences for the child. Other than adversely impacting the cognitive ability, a child’s nutritional status also influences the immune responses in varied and complex ways. A common thread links nutrition, immunity and infections. Nutritional deficiencies are known to affect various components of the immune system putting a child at a greater risk of developing a disease. The severity of malnutrition and the age of onset of nutritional deprivation often decide the extent of immunological impairment. A stunted, undernourished child is at a greater risk of various diseases. Infection and malnutrition overlap and interact; infact they form a vicious cycle. Undernutrition weakens the immune system, putting children at higher risk of more severe, frequent and prolonged bouts of illness. Looking at this from other end of the spectrum, undernutrition appears to be a consequence of repeated infections, which can further worsen the child’s nutritional status. Thus recurrent infections contribute to pathogenesis of malnutrition. This interaction between under nutrition and infection creates a potentially lethal cycle of worsening illness and deteriorating nutritional status. Critical nutrition interventions have the potential to break this cycle and are important for accelerating progress. Scrimshaw et al (1968) first described this vicious cycle of infection and under nutrition. His research stated that infections predispose to malnutrition, through reduced intake and absorption and diversion of nutrients away from growth, while malnutrition reduces immune function and increases the risk and/or severity of infections.

Immunization and improved nutrition are among the key factors in a multi-sectoral package of interventions for reducing childhood mortality and feature prominently in the Gates Grand Challenges in Global Health. Vaccination programs also stand to hugely benefit the malnourished population as well. Vaccination programs are particularly valuable health resource for settings that are in high-disease environment. Reforming children’s health status translates into higher worker productivity promoting economic success and poverty reduction for a nation. Improving nutritional status will further add to the overall success of the multi sectoral interventions that include immunization and vaccination programs undertaken by the government.


It is reassuring that the enormity of the adverse impacts of poor nutrition on a child’s growth and development are being recognized and acted upon aggressively. Entities such as Hilleman Laboratories understand and recognize the interplaying role of nutrition and immunity in improving child health and development and its impact on the economic sustainability of our nation and are looking ahead and promoting actions for transforming lives.
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Hilleman Laboratories is a global vaccine research & development organization focused on making affordable vaccines using innovation to address gaps that exist in low resource settings. Hilleman Labs acts as a catalyst in bridging the gap between academic research and product development by targeting novel vaccines and increasing the efficiency of existing vaccines. Know More

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